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Seminar : Dermal uptake of nicotine directly from air and the impact of clothing

2017-08-31

Title: Dermal uptake of nicotine directly from air and the impact of clothing
 
Speaker: Prof. Dr. Tunga Salthammer
Fraunhofer WKI
Department of Material Analysis and Indoor Chemistry
Braunschweig
Germany
 
Date: 31 August, 2017 (Thursday)
 
Time: 4:00 p.m.
 
Venue: Room 7-37, Haking Wong Building, HKU
 
Abstract:
In a pilot study it was shown that the dermal uptake of nicotine from cigarette smoke can be a relevant exposure pathway. On the basis of these preliminary results, scientists from the fields of building sciences, human-biomonitoring, gas-phase analytics, physical chemistry and modeling
collaborated to design a more detailed research plan, and experiments were performed in October 2016 at the Technical University of Denmark.  During all of the exposure experiments, the volunteers breathed clean air from hoods they wore. Nicotine (dissolved in water) was delivered to the 55 m3 exposure chamber from a step-motor driven syringe. In week 1, four volunteers wearing only shorts and two volunteers wearing clean cotton clothes were exposed in the chamber for five hours. In week 2, two of the bare-skin participants were again exposed in the chamber for five hours, and then showered immediately after exposure rather than waiting at least
24 h as they had done in week 1. The two participants who wore clean clothes in week 1 were now exposed wearing a shirt, socks and gloves that had been exposed to nicotine for almost a month. They wore clean full-length pants that had not been exposed. Urine samples were collected
before, during and after exposure and analyzed for nicotine, cotinine and 3OH-cotinine. The major results of the study can be summarized as follows:
a) dermal uptake, directly from air, is a meaningful exposure pathway for nicotine – comparable to inhalation; b) clean clothing acts as a barrier to dermal exposure from air; c) clothing that has absorbed nicotine can promote its dermal uptake; d) skin is a reservoir – delivery continues after
leaving chamber. The outcome emphasizes the advantage of interdisci¬pli-nary research designs, which are helpful to understand exposure scenarios to indoor pollutants.
 
About the speaker:
Tunga Salthammer earned a Doctor of Natural Science degree (Dr. rer. nat.) in Physical Chemistry from the Technical University of Braunschweig, Germany. He joined the Fraunhofer WKI in 1990, and has been the head of the Department of Material Analysis and Indoor Chemistry since 1996 and the deputy director of WKI since 2011. From 2003–2009, he was a Professor of Indoor Hygiene at the University of Applied Sciences Braunschweig/Wolfenbuettel. He is also an (Adjunct) Professor at Technical University of Braunschweig, Visiting Professor at the Technical
University of Denmark (2006–2007) and at Tsinghua University (May 2007). He is the past president of the ISIAQ Academy of Fellows. His research interests include analytical chemistry, VOC/SVOC emission studies on indoor materials using test chambers and cells, indoor
chemistry, airborne particles, and settled dust.
 
ALL INTERESTED ARE WELCOME
 
For further information, please contact Prof. Y. Li at 3917 2625.